BDBM50183656 (R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)silinan-1-ol::CHEMBL427215

SMILES COc1ccc(cc1)[C@H](CN(C)C)[Si]1(O)CCCCC1

InChI Key InChIKey=KIXBFSFRCBHKLN-INIZCTEOSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50183656   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of SERT (unknown origin) assessed as serotonin reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  251nMAssay Description:Inhibition of human NET expressed in MDCK cells assessed as decrease in [3H]-noradrenaline reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  109nMAssay Description:Inhibition of NET (unknown origin) assessed as noradrenaline reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  200nMAssay Description:Inhibition of noradrenaline reuptake at human recombinant noradrenaline transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of serotonin reuptake at human recombinant serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of dopamine reuptake at human recombinant dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  5.27E+3nMAssay Description:Inhibition of DAT (unknown origin) assessed as dopamine reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  251nMAssay Description:Inhibition of NET (unknown origin) assessed as noradrenaline reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  3.17E+3nMAssay Description:Inhibition of SERT (unknown origin) assessed as serotonin reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  109nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  5.27E+3nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  251nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  3.17E+3nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  2.63E+3nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  3.17E+3nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as decrease in [3H]-serotonin reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  5.27E+3nMAssay Description:Inhibition of human DAT expressed in CHOK1 cells assessed as decrease in [3H]-dopamine reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM50183656((R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)...)
Affinity DataIC50:  2.63E+3nMAssay Description:Inhibition of DAT (unknown origin) assessed as dopamine reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed