BDBM50198027 CHEMBL3921246
SMILES CCc1ccc(cc1)\N=C1/S\C(=C/c2ccnc(Nc3ccc(cn3)C(O)=O)c2)C(=O)N1C
InChI Key InChIKey=ZJQWORQRPDYKRS-KGQWDEOMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50198027
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University Of Berne
Curated by ChEMBL
University Of Berne
Curated by ChEMBL
Affinity DataKd: 1.50E+3nMAssay Description:Binding affinity to human PIK3CG expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Homo sapiens (Human))
University Of Berne
Curated by ChEMBL
University Of Berne
Curated by ChEMBL
Affinity DataKd: 480nMAssay Description:Binding affinity to human PIP5K2C expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of Aurora B kinase in human HeLa Kyoto cells assessed as effect on distribution of phspho-histone H3 ser10 level incubated for 20 hrsMore data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
University Of Berne
Curated by ChEMBL
University Of Berne
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 11nMAssay Description:Binding affinity to human Aurora C kinase expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition ass...More data for this Ligand-Target Pair
Affinity DataKd: 450nMAssay Description:Binding affinity to human DAPK2 expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition assayMore data for this Ligand-Target Pair
Affinity DataIC50: 760nMAssay Description:Inhibition of Aurora A kinase autophosphorylation at Thr288 in human HeLa Kyoto cells incubated for 20 hrsMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Berne
Curated by ChEMBL
University Of Berne
Curated by ChEMBL
Affinity DataKd: 120nMAssay Description:Binding affinity to auto-inhibited human CSF1R expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competitio...More data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Binding affinity to human Aurora B kinase expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition ass...More data for this Ligand-Target Pair
Affinity DataKd: 5nMAssay Description:Binding affinity to human Aurora A kinase expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition ass...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 19(Homo sapiens (Human))
University Of Berne
Curated by ChEMBL
University Of Berne
Curated by ChEMBL
Affinity DataKd: 2.90E+3nMAssay Description:Binding affinity to human YSK4 expressed in Escherichia coli BL21 cells incubated for 1 hr by active site directed binding competition assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged human Aurora A kinase (122 to 40 residues) expressed in Escherichia coli BL21 (DE3) Rosetta cells using biotinylated STK2 su...More data for this Ligand-Target Pair
Affinity DataEC50: 6.00E+3nMAssay Description:Inhibition of Aurora A kinase in human HeLa Kyoto cells assessed as induction of defective chromosome alignment during metaphase incubated for 20 hrsMore data for this Ligand-Target Pair