BDBM50199593 7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(4-(methylthio)phenyl)-1,2,3,4-tetrahydroisoquinoline::CHEMBL395368

SMILES CSc1ccc(cc1)C1CN(C)Cc2cc(OCCCN3CCC(F)CC3)ccc12

InChI Key InChIKey=ZYALYWXELCWDBL-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50199593   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(...)
Affinity DataKi:  2nMAssay Description:Binding affinity at human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(...)
Affinity DataKi:  2nMAssay Description:Binding affinity at rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(...)
Affinity DataKi:  2nMAssay Description:Binding affinity at human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(...)
Affinity DataKi:  2nMAssay Description:Binding affinity at rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(...)
Affinity DataKi:  4.20nMAssay Description:Binding affinity at human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(...)
Affinity DataKi:  5nMAssay Description:Binding affinity at rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(...)
Affinity DataKi:  6.5nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(...)
Affinity DataKi:  6.5nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(...)
Affinity DataKi:  15nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(...)
Affinity DataKi:  46nMAssay Description:Inhibition of [3H]WIN uptake in human DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199593(7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-4-(...)
Affinity DataKi:  118nMAssay Description:Inhibition of [3H]nisoxetine uptake in human NET expressed in MDCK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed