BDBM50199597 2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinopropoxy)-1,2,3,4-tetrahydroisoquinoline::CHEMBL246955

SMILES CSc1ccc(cc1)C1CN(C)Cc2cc(OCCCN3CCOCC3)ccc12

InChI Key InChIKey=XYYGFCDTBHAUSN-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50199597   

TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199597(2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinop...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity at rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199597(2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinop...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity at rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199597(2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinop...)
Affinity DataKi:  3nMAssay Description:Binding affinity at rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199597(2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinop...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity at human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199597(2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinop...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity at human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199597(2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinop...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity at human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199597(2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinop...)
Affinity DataKi:  10nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199597(2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinop...)
Affinity DataKi:  10nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199597(2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinop...)
Affinity DataKi:  11nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199597(2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinop...)
Affinity DataKi:  29nMAssay Description:Inhibition of [3H]WIN uptake in human DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50199597(2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinop...)
Affinity DataKi:  106nMAssay Description:Inhibition of [3H]nisoxetine uptake in human NET expressed in MDCK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed