BDBM50200432 CHEMBL3917803::US9763922, Example 222

SMILES COCCNC(=O)c1cccc(Nc2nn(CC3CC3)c3CCN(Cc23)C(C)=O)c1

InChI Key InChIKey=IMKSEBVXLVCTHC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50200432   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 50200432BDBM50200432(CHEMBL3917803 | US9763922, Example 222)
Affinity DataIC50: 3.28E+3nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50200432BDBM50200432(CHEMBL3917803 | US9763922, Example 222)
Affinity DataIC50: 4.40E+3nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 50200432BDBM50200432(CHEMBL3917803 | US9763922, Example 222)
Affinity DataIC50: 1.97E+4nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 50200432BDBM50200432(CHEMBL3917803 | US9763922, Example 222)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD4 bromodomain-1 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed