BDBM50203281 CHEMBL3971895

SMILES N#Cc1c(-c2cccc(Cl)c2)c2c(=O)[nH]c(=O)[nH]c2[nH]c1=O

InChI Key InChIKey=OLAIUOJBVWWLOO-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50203281   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Indian Institute of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50203281BDBM50203281(CHEMBL3971895)
Affinity DataEC50:  52nMAssay Description:Inhibition of IDO1 in IFNgamma-induced human MDA-MB-231 cells using tryptophan as substrate preincubated for 4 hrs followed by substrate addition for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2018
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Indian Institute of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50203281BDBM50203281(CHEMBL3971895)
Affinity DataIC50: 78nMAssay Description:Inhibition of N-terminus 6xHis-tagged human IDO1 expressed in Escherichia coli M15 using L-tryptophan as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2018
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Indian Institute of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50203281BDBM50203281(CHEMBL3971895)
Affinity DataKi:  98nMAssay Description:Inhibition of N-terminus 6xHis-tagged human IDO1 expressed in Escherichia coli M15 using L-tryptophan as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2018
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Indian Institute of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50203281BDBM50203281(CHEMBL3971895)
Affinity DataIC50: 296nMAssay Description:Inhibition of N-terminus 6xHis-tagged human IDO1 expressed in Escherichia coli M15 using L-tryptophan as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2018
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Indian Institute of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50203281BDBM50203281(CHEMBL3971895)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of N-terminal 6xHis-tagged human TDO expressed in Escherichia cli Rosetta (DE3) pLysS using L-tryptophan as substrate preincubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2018
Entry Details Article
PubMed