BDBM50203533 (6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide::(6S,7S)-N-hydroxy-6-{[(3R)-3-phenylpyrrolidin-1-yl]carbonyl}-5-azaspiro[2.5]octane-7-carboxamide::CHEMBL221698

SMILES ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CC[C@@H](C1)c1ccccc1

InChI Key InChIKey=XKPUKZQRNSFQLM-JYJNAYRXSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50203533   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50:  92nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50:  97nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50:  97nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50:  960nMAssay Description:Inhibition of MMP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50:  92nMAssay Description:Inhibition of HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)
Affinity DataIC50:  960nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed