BDBM50232542 CHEMBL4090531::US10323022, Example 135

SMILES CCOc1nn(c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1C)-c1ccccc1

InChI Key InChIKey=SQGLEZDWHPDRDX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50232542   

TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50: 6nMAssay Description:Inhibition of juxtamembrane region containing recombinant human N-terminal His6-tagged/GST-tagged TrkA (473 to 796 residues) expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50: 2.48E+3nMAssay Description:Inhibition of recombinant human TrkC expressed in DHFR deficient CHO cells assessed as inhibition of human neurotrophin-3-induced calcium influx by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human TrkB expressed in DHFR deficient CHO cells assessed as inhibition of human brain-derived neurotrophic factor-induced ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant human TrkA expressed in DHFR deficient CHO cells assessed as inhibition of human beta-nerve growth factor-induced calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50: 3.72E+4nMAssay Description:Inhibition of juxtamembrane region deficient recombinant human N-terminal His6-tagged/GST-tagged TrkA (498 to 796 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2019
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50: 100nMAssay Description:Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
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