BDBM50235833 CHEMBL4062803

SMILES Cc1c2ccc(cc2[nH]n1)Nc3nc4ccoc4c(n3)NC5CC5

InChI Key InChIKey=MDWXVGCLSBQVMP-UHFFFAOYSA-N

Data  62 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 63 hits for monomerid = 50235833   

TargetTyrosine-protein kinase SYK(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 23nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 24nMAssay Description:Inhibition of Syk (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataEC50:  34nMAssay Description:Inhibition of Syk in human Ramos B cells assessed as decrease in intracellular calcium flux measured for 3.5 mins by calcium-5 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetActivated CDC42 kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of TNK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of TTK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 2.75E+3nMAssay Description:Inhibition of JNK1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of RET (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 4.14E+3nMAssay Description:Inhibition of TYRO3 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 4.17E+3nMAssay Description:Inhibition of JAK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 16(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of STK16 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 4.79E+3nMAssay Description:Inhibition of FAK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDeath-associated protein kinase 3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 4.98E+3nMAssay Description:Inhibition of ZIPK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 5.22E+3nMAssay Description:Inhibition of ABL (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 5.94E+3nMAssay Description:Inhibition of ALK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 5.96E+3nMAssay Description:Inhibition of Fyn (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 6.01E+3nMAssay Description:Inhibition of LTK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of MAP4K2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 6.79E+3nMAssay Description:Inhibition of PAK4 kinase domain (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 7.51E+3nMAssay Description:Inhibition of Lck (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 7.54E+3nMAssay Description:Inhibition of CK1alpha1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 8.54E+3nMAssay Description:Inhibition of KDR (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 9.43E+3nMAssay Description:Inhibition of MAP4K4 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 9.96E+3nMAssay Description:Inhibition of GRK5 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DYRK1A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ACVR1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEK1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor-like protein(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MST1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of INSR (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DYRK1B (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKKE (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CLK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Prkcn (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CSF1R (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK8 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TBK1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK7 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Wee1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3B (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-MET (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1D(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CAMK1D (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK9 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKCtheta (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TrkB (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CAMK2A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235833(CHEMBL4062803)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK1(unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
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