BDBM50240469 CHEMBL4096341

SMILES [H][C@@]12CC[C@]([H])([C@H]1NC(=O)c1ccc(cc1Cl)-n1cnc(C)n1)N(C2)c1ncc(Cl)c2cnoc12

InChI Key InChIKey=PQCRELQHENQSGP-RQUSPXKASA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50240469   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240469(CHEMBL4096341)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by Whole-cell voltage clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240469(CHEMBL4096341)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in liver microsomes (unknown origin) assessed as formation of acetaminophen from phenacetin in presence of NADPH by LC-MS/MS ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240469(CHEMBL4096341)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in liver microsomes (unknown origin) assessed as formation of 4-hydroxydiclofenac from diclofenac in presence of NADPH by LC-MS/...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240469(CHEMBL4096341)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in liver microsomes (unknown origin) assessed as formation of 1-hydroxybufuralol from bufuralol in presence of NADPH by LC-MS/MS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240469(CHEMBL4096341)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in liver microsomes (unknown origin) assessed as formation of 4-hydroxymephenytoin from S-mephenytoin in presence of NADPH by L...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240469(CHEMBL4096341)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Rattus norvegicus)
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240469(CHEMBL4096341)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of rat coagulation factor 9aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240469(CHEMBL4096341)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of human coagulation factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240469(CHEMBL4096341)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in liver microsomes (unknown origin) assessed as formation of 1-hydroxymidazolam from midazolam in presence of NADPH by LC-MS/MS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed