BDBM50240717 2-{2-[3-(2-Carbamimidoylsulfanyl-ethyl)-phenyl]-ethyl}-isothiourea::CHEMBL107201

SMILES [H]/N=C(\N)/SCCc1cccc(c1)CCSC(=N)N

InChI Key InChIKey=YEUSLPIIQGZHQB-UHFFFAOYSA-N

Data  4 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50240717   

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50240717(2-{2-[3-(2-Carbamimidoylsulfanyl-ethyl)-phenyl]-et...)
Affinity DataKi:  37nMAssay Description:Inhibition of nNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50240717(2-{2-[3-(2-Carbamimidoylsulfanyl-ethyl)-phenyl]-et...)
Affinity DataKi:  47nMAssay Description:Inhibition of iNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50240717(2-{2-[3-(2-Carbamimidoylsulfanyl-ethyl)-phenyl]-et...)
Affinity DataKi:  250nMAssay Description:Inhibition of nNOS assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50240717(2-{2-[3-(2-Carbamimidoylsulfanyl-ethyl)-phenyl]-et...)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of eNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed