BDBM50241112 2-(2-Amino-phenylamino)-10,11-dihydro-dibenzo[a,d]cyclohepten-5-one::CHEMBL218962

SMILES c1ccc2c(c1)CCc3cc(ccc3C2=O)Nc4ccccc4N

InChI Key InChIKey=VMANCBCSTYKPPA-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50241112   

LigandPNGBDBM50241112(2-(2-Amino-phenylamino)-10,11-dihydro-dibenzo[a,d]...)
Affinity DataKd:  7.60nMAssay Description:Inhibition of non-phosphorylated human N-terminal His-P38alpha overexpressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by Kino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50241112(2-(2-Amino-phenylamino)-10,11-dihydro-dibenzo[a,d]...)
Affinity DataIC50: 50nMAssay Description:Inhibition of MAP kinase p38alpha assessed as phosphorylation of ATF-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 11/12/13/14(Human)
University of Zagreb

Curated by ChEMBL
LigandPNGBDBM50241112(2-(2-Amino-phenylamino)-10,11-dihydro-dibenzo[a,d]...)
Affinity DataIC50: 50nMAssay Description:Inhibition of MAPK p38 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50241112(2-(2-Amino-phenylamino)-10,11-dihydro-dibenzo[a,d]...)
Affinity DataIC50: 100nMAssay Description:Inhibition of p38alpha MAPK by cell-free enzyme immunosorbent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50241112(2-(2-Amino-phenylamino)-10,11-dihydro-dibenzo[a,d]...)
Affinity DataIC50: 100nMAssay Description:Inhibition of non-phosphorylated human N-terminal His-P38alpha overexpressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50241112(2-(2-Amino-phenylamino)-10,11-dihydro-dibenzo[a,d]...)
Affinity DataIC50: 104nMAssay Description:Inhibition of p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50241112(2-(2-Amino-phenylamino)-10,11-dihydro-dibenzo[a,d]...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of P38alpha in human THP-1 cells incubated for 30 mins by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)