BDBM50241748 CHEMBL518059::dihydro-beta-erythroidine

SMILES CO[C@H]1CC=C2CCN3CCC4=C(CC(=O)OC4)[C@@]23C1

InChI Key InChIKey=ALSKYCOJJPXPFS-XJKSGUPXSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50241748   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50241748(CHEMBL518059 | dihydro-beta-erythroidine)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]cytisine from alpha4/beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50241748(CHEMBL518059 | dihydro-beta-erythroidine)
Affinity DataKi:  1.05E+4nMAssay Description:Displacement of [3H]cytisine from alpha7 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50241748(CHEMBL518059 | dihydro-beta-erythroidine)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at (alpha4beta2)2alpha4 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced curre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/alpha-5/beta-2(Homo sapiens (Human))
University Of Chile

Curated by ChEMBL
LigandPNGBDBM50241748(CHEMBL518059 | dihydro-beta-erythroidine)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at (alpha4beta2)2alpha5 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced curre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50241748(CHEMBL518059 | dihydro-beta-erythroidine)
Affinity DataIC50:  410nMAssay Description:Antagonist activity at (alpha4beta2)2beta2 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced curren...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241748(CHEMBL518059 | dihydro-beta-erythroidine)
Affinity DataIC50:  1.00E+5nMAssay Description:Activity at rat alpha3beta4 nicotinic receptor expressed in KXalpha3beta4R2 cells assessed as nicotine-induced 86Rb+ effluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed