BDBM50246037 2,2,2-trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-yl)thiophen-2-yl)ethanone::CHEMBL471344

SMILES Cc1noc(n1)-c1ccc(s1)C(=O)C(F)(F)F

InChI Key InChIKey=PHNUPEDOQIENBU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50246037   

TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246037(2,2,2-trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  75nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246037(2,2,2-trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  650nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246037(2,2,2-trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  650nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246037(2,2,2-trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246037(2,2,2-trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246037(2,2,2-trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed