BDBM50246164 CHEMBL487242::N3-(2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine

SMILES COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccccc3)nc12

InChI Key InChIKey=KAFUZFJSHOPUIZ-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50246164   

TargetActivated CDC42 kinase 1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50246164(N3-(2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of ACK1 kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50246164(N3-(2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl...)
Affinity DataKi:  3nMAssay Description:Inhibition of histidine-tagged ACK1 (amino acids 117 to 489) expressed in SF9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50246164(N3-(2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl...)
Affinity DataKi:  20nMAssay Description:Inhibition of flag-tagged ACK1 autophosphorylation expressed in human 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed