BDBM50247920 Alendronate Sodium::Binosto::Fosamax::G-704650::MK-217

SMILES [Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O

InChI Key InChIKey=CAKRAHQRJGUPIG-UHFFFAOYSA-M

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50247920   

TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50:  460nMAssay Description:Inhibition of recombinant human farnesyl diphosphate synthase in expressed in Escherichia coli using GPP and [1-14C]IPP as substrate incubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Helmholtz Center For Infection Research (Hzi)

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MMP-3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFarnesyl pyrophosphate synthase(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of farnesyl diphosphate synthase in Balb/C mouse osteoclast assessed as reduction in [3H]MVL incorporation into nonsaponifiable lipids pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsopentenyl-diphosphate Delta-isomerase 1(Rattus norvegicus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of isopentenyl diphosphate isomerase in Sprague-Dawley rat liver S100 fraction preincubated for 10 min followed by MVA addition by HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Rattus norvegicus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of farnesyl diphosphate synthase in Sprague-Dawley rat liver S100 fraction using MVA as substrate preincubated for 10 min followed by MVA ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Helmholtz Center For Infection Research (Hzi)

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminal his6-tagged MMP-1 expressed in HEK293 cells by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Helmholtz Center For Infection Research (Hzi)

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MMP-2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFarnesyl pyrophosphate synthase(Mus musculus)
Korea University

Curated by ChEMBL
LigandPNGBDBM50247920(Alendronate Sodium | Binosto | Fosamax | G-704650 ...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of farnesyl diphosphate synthase in Balb/C mouse osteoclast assessed as reduction in [3H]MVL incorporation into prenylated proteins preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed