BDBM50249298 BEVYXXA::CHEMBL512351::N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide::betrixaban

SMILES COc1ccc(NC(=O)c2ccc(cc2)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1

InChI Key InChIKey=XHOLNRLADUSQLD-UHFFFAOYSA-N

Data  3 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50249298   

TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataKi:  0.117nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataKi:  0.120nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataKi:  1.80E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of tissue plasminogen activator (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of activated anticoagulant protein C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of plasmin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human thrombin using substrate S-2238 preincubated for 30 mins followed by substrate addition measured after 20 mins by micro plate rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human factor 10a using substrate S-2765 preincubated for 30 mins followed by substrate addition measured after 20 mins by micro plate r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human factor Xa using S-2222 as substrate preincubated for 30 mins followed by substrate addition and measured for 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant thrombin expressed in HEK293 cells using S-2238 as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human thrombin using acromogenic substrate S-2238 preincubated for 30 mins before substrate addition measured after 20 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed