BDBM50250664 CHEMBL4077586::US10961200, Compound 427::US11247971, Cmpd ID 427

SMILES OC(=O)c1csc(n1)-n1nc(cc1C(F)(F)F)-c1ccc(Cl)cc1

InChI Key InChIKey=MCQOZQWICARRLB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50250664   

TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50250664BDBM50250664(CHEMBL4077586 | US10961200, Compound 427 | US11247...)
Affinity DataIC50: 2.66E+4nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and in absence of EDTA by diaphorase/resazurin ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50250664BDBM50250664(CHEMBL4077586 | US10961200, Compound 427 | US11247...)
Affinity DataIC50: 2.77E+4nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and in absence of EDTA by diaphorase/resazurin ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2019
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50250664BDBM50250664(CHEMBL4077586 | US10961200, Compound 427 | US11247...)
Affinity DataIC50: 2.90E+4nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent