BDBM50250897 CHEMBL4081585::US10696655, Example 21::US11168070, Example 21

SMILES Cn1cc(cn1)-c1cc2CCCN(c3ccc4sc(=O)n(C)c4c3)c2cc1C(F)F

InChI Key InChIKey=WJHMCLBLUFFBIF-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50250897   

TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250897(CHEMBL4081585 | US10696655, Example 21 | US1116807...)
Affinity DataIC50:  69nMAssay Description:Inhibition of His tagged recombinant CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250897(CHEMBL4081585 | US10696655, Example 21 | US1116807...)
Affinity DataIC50:  64nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250897(CHEMBL4081585 | US10696655, Example 21 | US1116807...)
Affinity DataIC50:  64nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250897(CHEMBL4081585 | US10696655, Example 21 | US1116807...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of His tagged recombinant BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed