BDBM50252735 CHEMBL495084::N-Cyclopropyl-6-methyl-7-(1-o-tolylphthalazin-6-yl)benzo[d]-isoxazol-3-amine

SMILES Cc1ccccc1-c1nncc2cc(ccc12)-c1c(C)ccc2c(NC3CC3)noc12

InChI Key InChIKey=PQVHRPXGPBDRRS-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50252735   

TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50252735(N-Cyclopropyl-6-methyl-7-(1-o-tolylphthalazin-6-yl...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50252735(N-Cyclopropyl-6-methyl-7-(1-o-tolylphthalazin-6-yl...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50252735(N-Cyclopropyl-6-methyl-7-(1-o-tolylphthalazin-6-yl...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed