BDBM50254017 6-((4-fluorophenyl)(1H-imidazol-1-yl)methyl)benzo[d][1,3]dioxol-5-ol::CHEMBL513615::NSC-368280

SMILES Oc1cc2OCOc2cc1C(c1ccc(F)cc1)n1ccnc1

InChI Key InChIKey=WOTHQAYNAPHLDM-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50254017   

TargetAromatase(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50254017(6-((4-fluorophenyl)(1H-imidazol-1-yl)methyl)benzo[...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by Lineweaver-Burke plot in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAromatase(Human)
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50254017(6-((4-fluorophenyl)(1H-imidazol-1-yl)methyl)benzo[...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein disulfide-isomerase(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50254017(6-((4-fluorophenyl)(1H-imidazol-1-yl)methyl)benzo[...)
Affinity DataIC50: 670nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed