BDBM50264407 CHEMBL448998::Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl

SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1

InChI Key InChIKey=VUSRUVIDWSRKBU-UHFFFAOYSA-N

Data  2 KI  6 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50264407   

TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50264407(Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | CHEMBL4...)
Affinity DataIC50: 0.794nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in mouse HN9.10 cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50264407(Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | CHEMBL4...)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human delta opioid receptor expressed in mouse HN9.10 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50264407(Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | CHEMBL4...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50264407(Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | CHEMBL4...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50264407(Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | CHEMBL4...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50264407(Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | CHEMBL4...)
Affinity DataIC50: 4.80nMAssay Description:Agonist activity at delta opioid receptor in ICR mouse vas deferens assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50264407(Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | CHEMBL4...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at rat mu opioid receptor expressed in mouse HN9.10 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50264407(Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | CHEMBL4...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at rat mu opioid receptor expressed in mouse HN9.10 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50264407(Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | CHEMBL4...)
Affinity DataIC50: 61nMAssay Description:Agonist activity at mu opioid receptor in Hartley guinea pig ileum longitudinal muscle with myenteric plexus assessed as inhibition of electrically-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50264407(Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | CHEMBL4...)
Affinity DataKi:  700nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50264407(Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | CHEMBL4...)
Affinity DataIC50: 2.51E+3nMAssay Description:Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed