BDBM50267844 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane::CHEMBL490843

SMILES C[N+]1([C@H]2CC[C@@H]1CC(C2)OC3c4ccccc4CCc5c3cccc5)C

InChI Key InChIKey=BADPXOSJBUEVTR-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50267844   

LigandPNGBDBM50267844(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylox...)
Affinity DataIC50: 880nMAssay Description:Activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as inhibition of acetylcholine-evoked currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50267844(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylox...)
Affinity DataIC50: 210nMAssay Description:Activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as inhibition of acetylcholine-evoked currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
Institute

Curated by ChEMBL
LigandPNGBDBM50267844(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylox...)
Affinity DataKi:  63.1nMAssay Description:Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50267844(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylox...)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in human SH-SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed