BDBM50268380 (+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[chroman-2,4'-piperidine]-1'-carboxamide::4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[chroman-2,4'-piperidine]-1'-carboxamide::4-oxo-N-((trans)-2-phenylcyclopropyl)spiro[chroman-2,4'-piperidine]-1'-carboxamide::CHEMBL496189

SMILES O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CC1)CC(=O)c1ccccc1O2

InChI Key InChIKey=SWEAYHBSAXRXDZ-MOPGFXCFSA-N

Data  15 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50268380   

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Voltage-gated sodium channel subunit alpha Nav1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50:  9nMAssay Description:Inhibition of rat soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET productionMore data for this Ligand-Target Pair
TargetEpoxide hydrolase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50: >100nMAssay Description:Inhibition of human microsomal epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50: >100nMAssay Description:Inhibition of human microsomal epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Voltage-gated sodium channel subunit alpha Nav1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50:  9nMAssay Description:Inhibition of rat soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50268380((+/-)-4-oxo-N-((tans)-2-phenylcyclopropyl)spiro[ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair