BDBM50271669 CHEMBL4127932
SMILES C[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCC2)C(=O)N2CC3(C2)CS(=O)(=O)C3)c(Cl)c1Cl)C(F)(F)F
InChI Key InChIKey=BSSPFSBICAYDDO-LBPRGKRZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50271669
Affinity DataKd: 7.40E+3nMAssay Description:Binding affinity to recombinant human RORbeta LBD (201 to 452 residues) expressed in Escherichia coli BL21 (DE3) GOLD by 1,8-ANS dye-based thermofluo...More data for this Ligand-Target Pair
Affinity DataKd: 1.40nMAssay Description:Binding affinity to recombinant human RORgamma LBD (237 to 497 residues) expressed in Escherichia coli BL21 (DE3) GOLD by 1,8-ANS dye-based thermoflu...More data for this Ligand-Target Pair
Affinity DataEC50: 284nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in IL17A productionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated...More data for this Ligand-Target Pair