BDBM50273512 1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)phenyl]-3-methylbutan-1-one::CHEMBL458298

SMILES CC(C)CC(=O)c1ccc(OC(F)F)c(OC2CCOC2)c1

InChI Key InChIKey=IXURVUHDDXFYDR-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50273512   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50273512(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Affinity DataIC50:  26nMAssay Description:Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation countingMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50273512(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human cloned PDE5A1 expressed in Escherichia coli BL21 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50273512(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Affinity DataIC50:  26nMAssay Description:Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation countingMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50273512(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PDE4D2 (1 to 507 residues) (unknown origin) by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50273512(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human cloned PDE9A2 expressed in Escherichia coli BL21 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50273512(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human cloned PDE2A3 expressed in Escherichia coli BL21 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50273512(1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human cloned PDE7A1 catalytic domain expressed in Escherichia coli BL21 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed