BDBM50277361 4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy)phenyl)isothiazole-3-carboxamide::CHEMBL475509

SMILES FC(F)(F)Oc1cccc(NC(=O)c2nscc2NCc2ccncc2)c1

InChI Key InChIKey=HPQJCFJZSWQYAT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50277361   

TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277361(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy...)
Affinity DataIC50:  260nMAssay Description:Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277361(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy...)
Affinity DataIC50:  33nMAssay Description:Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Decode

Curated by ChEMBL
LigandPNGBDBM50277361(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethoxy...)
Affinity DataIC50:  41nMAssay Description:Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed