BDBM50279346 CHEMBL4175904

SMILES O=C(Nc1cc(cc2[nH]ncc12)-c1ccc2cc[nH]c2c1)c1ccccn1

InChI Key InChIKey=VHXRPEQBBZVPFA-UHFFFAOYSA-N

Data  5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50279346   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50279346(CHEMBL4175904)Copy SMILESCopy InChI

Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/14/2020
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50279346(CHEMBL4175904)Copy SMILESCopy InChI

Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/14/2020
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50279346(CHEMBL4175904)Copy SMILESCopy InChI

Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/14/2020
Entry Details Article
Copy BDB DOIPubMed
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TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50279346(CHEMBL4175904)Copy SMILESCopy InChI

Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of GSK3beta (unknown origin) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/14/2020
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50279346(CHEMBL4175904)Copy SMILESCopy InChI

Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate pretreated for 15 mins followed by substrate addition measured after 1 hrMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/14/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL