BDBM50289303 5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-1lambda*4*-imidazo[2,1-b]thiazole::5-(4-Methanesulfonyl-phenyl)-6-phenyl-imidazo[2,1-b]thiazole::CHEMBL146742::L-766112

SMILES CS(=O)(=O)c1ccc(cc1)-c1c(nc2sccn12)-c1ccccc1

InChI Key InChIKey=LLCRQHGZDKIAJY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50289303   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cellstransfected with human cyclooxygenase-...More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-...)
Affinity DataIC50:  900nMAssay Description:In vivo ability of the compound to inhibit cyclooxygenase-2 enzyme in human whole blood was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-...)
Affinity DataIC50:  16nMAssay Description:In vivo ability of the compound to inhibit cyclooxygenase-1 enzyme in human whole blood was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human COX2 expressed in CHO cells assessed as reduction in arachidonic acid-stimulated PGE2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human COX-2 transfected in CHO cells using arachidonic acid as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human COX1 expressed in CHO cells assessed as reduction in arachidonic acid-stimulated PGE2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-3,5-dihydro-...)
Affinity DataIC50: >3.00E+4nMAssay Description:In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cellstransfected with human cyclooxygenase-...More data for this Ligand-Target Pair
In DepthDetails Article