BDBM50293162 CHEMBL525194::N-cyclopropyl-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine::N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine

SMILES C1CC1Nc1nccc(n1)-c1cnn2ncccc12

InChI Key InChIKey=CAGHIASAHLPQMS-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50293162   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293162(CHEMBL525194 | N-cyclopropyl-4-(pyrazolo[1,5-b]pyr...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293162(CHEMBL525194 | N-cyclopropyl-4-(pyrazolo[1,5-b]pyr...)
Affinity DataIC50:  80nMAssay Description:Inhibition of CDK4 by radioactive glutathione plate-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293162(CHEMBL525194 | N-cyclopropyl-4-(pyrazolo[1,5-b]pyr...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human CDK2 by HTRF assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293162(CHEMBL525194 | N-cyclopropyl-4-(pyrazolo[1,5-b]pyr...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of GSK3beta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed