BDBM50293683 2-(2-methoxyphenylthio)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine::CHEMBL551634

SMILES COc1ccccc1Sc1nc(Nc2cc(C)n[nH]2)c2ccccc2n1

InChI Key InChIKey=CWQTZVUENDFTLF-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50293683   

TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50293683BDBM50293683(2-(2-methoxyphenylthio)-N-(5-methyl-1H-pyrazol-3-y...)
Affinity DataKi:  24nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50293683BDBM50293683(2-(2-methoxyphenylthio)-N-(5-methyl-1H-pyrazol-3-y...)
Affinity DataKi:  216nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50293683BDBM50293683(2-(2-methoxyphenylthio)-N-(5-methyl-1H-pyrazol-3-y...)
Affinity DataKi:  995nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50293683BDBM50293683(2-(2-methoxyphenylthio)-N-(5-methyl-1H-pyrazol-3-y...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed