BDBM50296348 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine::CHEMBL551064::NVP-AEW541

SMILES Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@@H](C1)N1CCC1

InChI Key InChIKey=USVCWSAJUAARAL-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50296348   

TargetInsulin-like growth factor 1 receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 86nMAssay Description:Inhibition of IGF1R by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin receptor(Mouse)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 140nMAssay Description:Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Mouse)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of IGF1R-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of insulin receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BCR-ABL p210More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(NVP-AEW541 | 7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed