BDBM50304221 CHEMBL593760::N-[4-(Benzo[d]thiazol-2''-yl)-3-fluorophenyl]-7'-methoxy-6'-[3-(4-methylpiperazin-1-yl)propoxy]quinazolin-4'-amine

SMILES COc1cc2ncnc(Nc3ccc(-c4nc5ccccc5s4)c(F)c3)c2cc1OCCCN1CCN(C)CC1

InChI Key InChIKey=DIOOREPVPOCQKL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50304221   

TargetAurora kinase A(Human)
4Sc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304221BDBM50304221(N-[4-(Benzo[d]thiazol-2''-yl)-3-fluorophenyl]-7'-m...)
Affinity DataIC50: 200nMAssay Description:Inhibition of Aurora-A by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
4Sc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304221BDBM50304221(N-[4-(Benzo[d]thiazol-2''-yl)-3-fluorophenyl]-7'-m...)
Affinity DataIC50: 670nMAssay Description:Inhibition of Aurora-B by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
4Sc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304221BDBM50304221(N-[4-(Benzo[d]thiazol-2''-yl)-3-fluorophenyl]-7'-m...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of wild type EGF-R by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
4Sc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304221BDBM50304221(N-[4-(Benzo[d]thiazol-2''-yl)-3-fluorophenyl]-7'-m...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of TIE2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50304221BDBM50304221(N-[4-(Benzo[d]thiazol-2''-yl)-3-fluorophenyl]-7'-m...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of PDGFRbeta by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50304221BDBM50304221(N-[4-(Benzo[d]thiazol-2''-yl)-3-fluorophenyl]-7'-m...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERBB2 by microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed