BDBM50304413 CHEMBL596447::cis-2-[4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-benzyl]-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one

SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(CN3CCC4(CC3)OCCO4)cc2)C(=O)[C@@H]2CC=CC[C@H]12

InChI Key InChIKey=OQGFHEKSYOZJBE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304413   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304413(cis-2-[4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethy...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed