BDBM50304414 CHEMBL603626::cis-4-(3,4-Dimethoxyphenyl)-2-[4-(piperidin-1-ylmethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one

SMILES COc1ccc(cc1OC)C1=NN(Cc2ccc(CN3CCCCC3)cc2)C(=O)[C@@H]2CC=CC[C@H]12

InChI Key InChIKey=SEHHXWJFLFPSLC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50304414   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Kyoto 601-8550

Curated by ChEMBL
LigandPNGBDBM50304414(cis-4-(3,4-Dimethoxyphenyl)-2-[4-(piperidin-1-ylme...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed