BDBM50307876 (S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide dihydrochloride::CHEMBL598849::US11584714, Compound 1027

SMILES N[C@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N

InChI Key InChIKey=RMYIJADBJGXIMY-ZWKOTPCHSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50307876   

TargetProthrombin(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50307876((S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbam...)
Affinity DataKi:  10nMAssay Description:Inhibition of human alpha-thrombin using tPa (CH3SO2-D-Cha-Gly-Arg-pNA.AcOH) as chromogenic substrate by kinetic photometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50307876((S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbam...)
Affinity DataKi:  23nMAssay Description:Binding affinity to human thrombin by standard kinetic photometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM50307876((S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbam...)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
The State University Of New York

Curated by ChEMBL
LigandPNGBDBM50307876((S)-1-((R)-2-amino-2-cyclohexylacetyl)-N-(4-carbam...)
Affinity DataKi: <500nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In DepthDetails US Patent