BDBM50308984 AdoCys::CHEMBL597532::S-Adenosylhomocysteine

SMILES N[C@H](CCSC[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)n1cnc2c(N)ncnc12)C(O)=O

InChI Key InChIKey=ZJUKTBDSGOFHSH-NPLZWRLCSA-N

Data  18 Kd  18 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50308984   

TargetPhosphoethanolamine N-methyltransferase 1(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  700nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 2(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  6.10E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 1(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  1.10E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 1(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  1.60E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 1(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  2.50E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 2(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  2.00E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 2(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  2.50E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 2(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  3.00E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 2(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  4.20E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 2(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  5.40E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 1(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  2.90E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 1(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  2.20E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 1(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  1.30E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 1(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  900nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 2(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  8.60E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 2(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  6.00E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 2(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  9.30E+3nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoethanolamine N-methyltransferase 1(Caenorhabditis elegans)
Washington University

LigandPNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
Affinity DataKd:  800nMpH: 7.5 T: 2°CAssay Description:For standard ITC analysis of ligand binding, proteins were dialyzed overnight in 25 mm Hepes (pH 7.5), 100 mm NaCl, 5 mm ??-mercaptoethanol, and 5% g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 18 hits for monomerid = 50308984   

CellPhosphoehtnaolamine Methyltransferases 1 (PMT1)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -8.12kcal/mole −TΔS°: 9.93kcal/mole ΔH°: -9.79kcal/mole
pH: 7.5 T: 4.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 2 (PMT2)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -6.69kcal/mole −TΔS°: 9.93kcal/mole ΔH°: -16.5kcal/mole
pH: 7.5 T: 4.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 2 (PMT2)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -6.93kcal/mole −TΔS°: 5.03kcal/mole ΔH°: -11.9kcal/mole
pH: 7.5 T: 4.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 2 (PMT2)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -6.69kcal/mole −TΔS°: 5.76kcal/mole ΔH°: -12.4kcal/mole
pH: 7.5 T: 4.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 2 (PMT2)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -6.93kcal/mole −TΔS°: -0.265kcal/mole ΔH°: -6.69kcal/mole
pH: 7.5 T: 4.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 1 (PMT1)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.88kcal/mole −TΔS°: 1.20kcal/mole ΔH°: -9.08kcal/mole
pH: 7.5 T: 5.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 1 (PMT1)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.88kcal/mole −TΔS°: 4.06kcal/mole ΔH°: -12.0kcal/mole
pH: 7.5 T: 10.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 1 (PMT1)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.88kcal/mole −TΔS°: 6.68kcal/mole ΔH°: -14.6kcal/mole
pH: 7.5 T: 15.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 1 (PMT1)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.88kcal/mole −TΔS°: 9.80kcal/mole ΔH°: -17.7kcal/mole
pH: 7.5 T: 20.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 1 (PMT1)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.64kcal/mole −TΔS°: 11.5kcal/mole ΔH°: -19.2kcal/mole
pH: 7.5 T: 25.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 2 (PMT2)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.40kcal/mole −TΔS°: 2.19kcal/mole ΔH°: -9.31kcal/mole
pH: 7.5 T: 5.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 2 (PMT2)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.40kcal/mole −TΔS°: 2.84kcal/mole ΔH°: -10.1kcal/mole
pH: 7.5 T: 10.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 2 (PMT2)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.40kcal/mole −TΔS°: 3.58kcal/mole ΔH°: -10.8kcal/mole
pH: 7.5 T: 15.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 2 (PMT2)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.17kcal/mole −TΔS°: 4.55kcal/mole ΔH°: -11.7kcal/mole
pH: 7.5 T: 20.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 2 (PMT2)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.17kcal/mole −TΔS°: 5.48kcal/mole ΔH°: -12.6kcal/mole
pH: 7.5 T: 25.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 1 (PMT1)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.40kcal/mole −TΔS°: 7.94kcal/mole ΔH°: -15.2kcal/mole
pH: 7.5 T: 4.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 1 (PMT1)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.64kcal/mole −TΔS°: 8.61kcal/mole ΔH°: -15.9kcal/mole
pH: 7.5 T: 4.00°C 
In DepthDetails ArticlePubMed
CellPhosphoehtnaolamine Methyltransferases 1 (PMT1)(Caenorhabditis elegans)
Washington University

SyringePNGBDBM50308984(AdoCys | CHEMBL597532 | S-Adenosylhomocysteine)
ITC DataΔG°: -7.88kcal/mole −TΔS°: 9.93kcal/mole ΔH°: -17.8kcal/mole
pH: 7.5 T: 4.00°C 
In DepthDetails ArticlePubMed