BDBM50318073 8-{[2-Acetyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1096028

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c(c1)C(C)=O

InChI Key InChIKey=BNGFMEOSJHFCLA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50318073   

TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318073BDBM50318073(8-{[2-Acetyl-4-(4-methylpiperazin-1-yl)phenyl]amin...)
Affinity DataIC50: 464nMAssay Description:Inhibition of GST-tagged PLK1 expressed in H5 insect cells assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318073BDBM50318073(8-{[2-Acetyl-4-(4-methylpiperazin-1-yl)phenyl]amin...)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of Plk3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318073BDBM50318073(8-{[2-Acetyl-4-(4-methylpiperazin-1-yl)phenyl]amin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318073BDBM50318073(8-{[2-Acetyl-4-(4-methylpiperazin-1-yl)phenyl]amin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Plk2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318073BDBM50318073(8-{[2-Acetyl-4-(4-methylpiperazin-1-yl)phenyl]amin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed