BDBM50318075 CHEMBL1098059::ethyl 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

SMILES CCOC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3)nc-21

InChI Key InChIKey=XCLOVJZYWDYYRT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50318075   

TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318075BDBM50318075(ethyl 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyra...)
Affinity DataIC50: 251nMAssay Description:Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Jiangnan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318075BDBM50318075(ethyl 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyra...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK2/Cyclin A2 (unknown origin) using FAM-labeled peptide as substrate after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Jiangnan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318075BDBM50318075(ethyl 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyra...)
Affinity DataIC50: 3.24E+3nMAssay Description:Inhibition of CDK4/Cyclin D3 (unknown origin) using FAM-labeled peptide as substrate after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Jiangnan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318075BDBM50318075(ethyl 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyra...)
Affinity DataIC50: 7.36E+3nMAssay Description:Inhibition of CDK6/Cyclin D3 (unknown origin) using FAM-labeled peptide as substrate after 40 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318075BDBM50318075(ethyl 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318075BDBM50318075(ethyl 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged PLK1 expressed in H5 insect cells assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed