BDBM50320589 CHEMBL1164493::Isopropyl 2-(3-acetyl-5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,4,6-trimethylpyridin-1(4H)-yl)acetate

SMILES CC(=O)C1=C(C)N(CC(=O)OC(C)C)C(C)=C(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNC2CC2)C1C

InChI Key InChIKey=AYTFEPLGCVRICQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50320589   

TargetBeta-secretase 1(Human)
Institute of Science and Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320589BDBM50320589(Isopropyl 2-(3-acetyl-5-((2S,3R)-4-(cyclopropylami...)
Affinity DataIC50: 2.93E+4nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with pCDNA-neo-SEAP-APP assessed as secreted alkaline phosphatase after cleavage of beta-site o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed