BDBM50331033 (Z)-5-(2-Diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-3-methyl-6,7,8,9-tetrahydro-1H,5H-1,5-diaza-cyclopentacycloocten-4-one::CHEMBL1277161

SMILES CCN(CC)CCN1CCCCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O

InChI Key InChIKey=BMWHAGVKNLRXNW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50331033   

TargetMast/stem cell growth factor receptor Kit(Human)
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331033((Z)-5-(2-Diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2...)
Affinity DataIC50: 9nMAssay Description:Inhibition of c-Kit after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331033((Z)-5-(2-Diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human PDGFRbeta after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331033((Z)-5-(2-Diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2...)
Affinity DataIC50: 112nMAssay Description:Inhibition of human VEGFR2 after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331033((Z)-5-(2-Diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2...)
Affinity DataIC50: 215nMAssay Description:Inhibition of VEGFR2-induced cell proliferation in HUVEC after 72 hrs by sulforhodamine B methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed