BDBM50333565 3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylamino)-pyrimidin-2-ylamino]-7,8-dihydro-6H-5-oxa-9-aza-benzocycloheptene-9-carboxylic acid 2-methoxy-ethyl ester::CHEMBL1642139

SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OCCOC)ncc1Cl

InChI Key InChIKey=DQILXXVPFRTBOV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50333565   

TargetHepatocyte growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50333565(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Affinity DataIC50: 50nMAssay Description:Inhibition of c-Met expressed in human GTL-16 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50333565(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Affinity DataIC50: 81nMAssay Description:Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50333565(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Affinity DataIC50: 800nMAssay Description:Inhibition of insulin receptor after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed