BDBM50336507 4-pyridinecarbohydrazide(Isoniazid)::CHEMBL64::Dow-isoniazid::Hyzyd::INH::ISONICOTINIC ACID HYDRAZIDE(ISONIAZIDE)::Isoniazid (INH)::Isonicotinic acid hydrazide (Isoniazid)::Isonicotinic acid hydrazide(Isoniazid)::Isonicotinylhydrazine::Laniazid::Nydrazid::Rimifon::Stanozide::isoniazid::isonicotinamide::isonicotinhydrazide::isonicotinohydrazide::isonicotinyl hydrazide::pyridine-4-carbohydrazide
SMILES NNC(=O)c1ccncc1
InChI Key InChIKey=QRXWMOHMRWLFEY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50336507
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology
Curated by ChEMBL
Birla Institute of Technology
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase using pantoic acid as substrate and beta-alanine as reactant assessed as NAD+ format...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Institute of Technology & Science-Pilani
Curated by ChEMBL
Institute of Technology & Science-Pilani
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as inhibition of DNA supercoiling after 30 mins by electrophoresisMore data for this Ligand-Target Pair
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology
Curated by ChEMBL
Birla Institute of Technology
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3) by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human MPOMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Irreversible inhibition of MPO (unknown origin)More data for this Ligand-Target Pair
TargetPantothenate synthetase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology
Curated by ChEMBL
Birla Institute of Technology
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis pantothenate synthetase expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 8.29E+3nMAssay Description:Inhibition of recombinant Mycobacterium tuberculosis InhA expressed in Escherichia coli Rosette(DE3) pLysS using trans-2-decenoyl-N-acetylcysteamine ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in enzyme-mediated supercoiling of relaxed pBR322 DNA measured after 60 mins by elect...More data for this Ligand-Target Pair
TargetIsocitrate lyase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology
Birla Institute of Technology
Affinity DataIC50: 4.56E+5nMT: 2°CAssay Description:Isocitrate lyase activity was determined at 37°C by measuringthe formation of glyoxylate phenylhydrazone at 324 nm [Bai et al., Drug Dev. Res., 6...More data for this Ligand-Target Pair
TargetPutative FAD-containing monooxygenase MymA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Miranda House
Miranda House
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of MymA activity by INH was checked using different concentrations (0-12 um) of INH, 100 um of trimeth- ylamine and 5 mg of MymA along wit...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:The fluorescence-based assay outlined in Figure 2 a was performed in black, low volume 384-well plates with a fi nal volume of 10 L per well. Nine uL...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Gel-based assays were performed by combining 4 µL of OGG1 (62.5 nM) with 1 µL of inhibitor or buffer. Substrate (5 µL, 50 nM) was added to bring the ...More data for this Ligand-Target Pair
Target3-oxoacyl-[acyl-carrier-protein] synthase 3(Escherichia coli)
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Escherichia coli KAS3 expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of MIF tautomerase (unknown origin) using 4-HPP as substrate preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataKd: <0.400nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv InhA assessed as dissociation constant in presence of NADH, octenoyl-CoA and KatGMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataKi: 0.75nMAssay Description:Binding affinity to wild type Mycobacterium tuberculosis InhA assessed as inhibition constant in presence of NADH, DD-CoA by spectrophotometry based ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Texas A&M University
Curated by ChEMBL
Texas A&M University
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of Mycobacterium tuberculosis dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Nanjing University
Curated by ChEMBL
Nanjing University
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Binding affinity to wild type Mycobacterium tuberculosis InhA assessed as inhibition constant for formation of enzyme-inhibitor complex in presence o...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+4nMAssay Description:Mechanism based inhibition of human cytochrome P450 2C19 evaluated using TolbutamideMore data for this Ligand-Target Pair
Affinity DataKi: 3.60E+4nMAssay Description:Mechanism based inhibition of human cytochrome P450 3A4 measured by testosterone 6-beta hydroxylation using human liver microsomesMore data for this Ligand-Target Pair
Affinity DataKi: 5.60E+4nMAssay Description:Mechanism based inhibition of human cytochrome P450 1A2 measured by formation of 6-hydroxywarfarinMore data for this Ligand-Target Pair
Affinity DataKi: 6.00E+4nMAssay Description:Mechanism based inhibition of human cytochrome P450 2A6 measured by coumarin 7-hydroxylationMore data for this Ligand-Target Pair
Affinity DataKi: 3.74E+5nMAssay Description:Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using a recombinant systemMore data for this Ligand-Target Pair
Affinity DataKi: 1.70E+5nMAssay Description:Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using human liver microsomesMore data for this Ligand-Target Pair