BDBM50337281 3-[N-(4-nitrophenyl)amino]benzoic acid::CHEMBL1682200::US9271961, 5

SMILES OC(=O)c1cccc(Nc2ccc(cc2)[N+]([O-])=O)c1

InChI Key InChIKey=YRZASYCIZSWCKB-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50337281   

TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  3.27E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  740nMAssay Description:Inhibition of COX2 expressed in baculovirus infected SF-21 cells assessed as formation of PGH2 from PGG2 using arachidonic acid as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  3.40E+3nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  6.74E+3nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: >5.00E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  4.60E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  3.08E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  740nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  36nMAssay Description:Inhibition of AKR1C3 by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of AKR1C2 by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  6.74E+3nMAssay Description:Inhibition of recombinant AKR1C1 assessed as enzyme catalyzed oxidation of S-tetralol by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  3.27E+4nMAssay Description:Inhibition of recombinant AKR1C4 assessed as enzyme catalyzed oxidation of S-tetralol by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  3.08E+4nMAssay Description:Inhibition of recombinant COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  740nMAssay Description:Inhibition of recombinant COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  6.74E+3nMAssay Description:Inhibition of recombinant AKR1C1 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  3.27E+4nMAssay Description:Inhibition of recombinant AKR1C4 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant AKR1C3 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  3.38E+3nMAssay Description:Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of recombinant AKR1B10 assessed as NADP+ dependent reduction of DL-glyceraldehyde by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
University of Pennsylvania

US Patent
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant AKR1B1 assessed as NADP+ dependent reduction of DL-glyceraldehyde by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50337281(3-[N-(4-nitrophenyl)amino]benzoic acid | CHEMBL168...)
Affinity DataIC50:  36nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In DepthDetails US Patent