BDBM50341240 (3R,6S)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl)-6-methyl-N-phenylpiperidine-3-carboxamide::CHEMBL1765736

SMILES C[C@H]1CC[C@H](CN1c1cc(nc(N)n1)-c1ccc2c(N)n[nH]c2c1)C(=O)Nc1ccccc1

InChI Key InChIKey=TXXYVBLFLGPQOR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50341240   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341240BDBM50341240((3R,6S)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyri...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341240BDBM50341240((3R,6S)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyri...)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341240BDBM50341240((3R,6S)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyri...)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341240BDBM50341240((3R,6S)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyri...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341240BDBM50341240((3R,6S)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyri...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341240BDBM50341240((3R,6S)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyri...)
Affinity DataIC50: 2.93E+4nMAssay Description:Inhibition of PDK1-mediated AKT phosphorylation at Thr308 residue in human PC3 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341240BDBM50341240((3R,6S)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyri...)
Affinity DataIC50: 2.93E+4nMAssay Description:Inhibition of PDK1-mediated RSK phosphorylation at Ser221 residue in human PC3 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed