BDBM50341307 CHEMBL1766045::N',N'-Dimethyl-aminothiazolo[5,4-b]-N-fluoropropylmethylmorphinan

SMILES CN(C)c1nc2cc3c(C[C@@H]4[C@@H]5CCCC[C@]35CCN4CCCF)cc2s1

InChI Key InChIKey=ITTKSQDJXLDVIA-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50341307   

TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50341307(N',N'-Dimethyl-aminothiazolo[5,4-b]-N-fluoropropyl...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50341307(N',N'-Dimethyl-aminothiazolo[5,4-b]-N-fluoropropyl...)
Affinity DataKi:  76nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50341307(N',N'-Dimethyl-aminothiazolo[5,4-b]-N-fluoropropyl...)
Affinity DataKi:  420nMAssay Description:Displacement of [3H]Naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed