BDBM50343246 CHEMBL1773572::N-(6-(2-(2-Phenylpropan-2-ylamino)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1ccnc(NC(C)(C)c2ccccc2)n1

InChI Key InChIKey=YWWPYGURSDURBZ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343246   

LigandPNGBDBM50343246(CHEMBL1773572 | N-(6-(2-(2-Phenylpropan-2-ylamino)...)
Affinity DataKi:  24nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50343246(CHEMBL1773572 | N-(6-(2-(2-Phenylpropan-2-ylamino)...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50343246(CHEMBL1773572 | N-(6-(2-(2-Phenylpropan-2-ylamino)...)
Affinity DataIC50: >6.00E+3nMAssay Description:Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed