BDBM50346613 CHEMBL470029::Oleanonic Acid

SMILES CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O

InChI Key InChIKey=FMIMFCRXYXVFTA-FUAOEXFOSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50346613   

TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50346613(CHEMBL470029 | Oleanonic Acid)
Affinity DataIC50:  1.79E+4nMAssay Description:Inhibition of rabbit muscle GPaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50346613(CHEMBL470029 | Oleanonic Acid)
Affinity DataIC50:  1.79E+4nMAssay Description:Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Dartmouth College

Curated by ChEMBL
LigandPNGBDBM50346613(CHEMBL470029 | Oleanonic Acid)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of inducible nitric oxide synthase in activated macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50346613(CHEMBL470029 | Oleanonic Acid)
Affinity DataIC50:  5.32E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetTissue factor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50346613(CHEMBL470029 | Oleanonic Acid)
Affinity DataIC50:  0.221nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50346613(CHEMBL470029 | Oleanonic Acid)
Affinity DataIC50:  5.32E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50346613(CHEMBL470029 | Oleanonic Acid)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human recombinant PTP1B after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed