BDBM50359359 CHEMBL1929238

SMILES CC(C)(C)c1cc(c(s1)NC(=O)Nc2cccc(c2Cl)Cl)C(=O)N3CCC(=O)N(CC3)CCN(C)C

InChI Key InChIKey=SIUIQMQVKUUQQF-UHFFFAOYSA-N

Data  148 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 148 hits for monomerid = 50359359   

TargetMitogen-activated protein kinase 14(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 22nMAssay Description:Inhibition of P38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 11/12/13/14(Human)
University of Zagreb

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 22nMAssay Description:Inhibition of MAPK p38 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 22nMAssay Description:Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into GST-ATF2 substrate preincubated for 20 mins before substrate addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 11(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 50nMAssay Description:Inhibition of P38beta2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 550nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of CAMK2betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of DDR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of EPHB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of EPHB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of TRKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of JNK2alpha2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CAMK2deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of PKCdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of EPHA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of SGK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 13(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of P38deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of P38gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 3(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PASKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 5(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 6(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PHKgamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PKCbeta1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PKCmuMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PKCgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetPolycystin-2(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PKD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CK2alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL2(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ABL2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of c-SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetDeath-associated protein kinase 1(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of DAPK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Ansaris

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
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