BDBM50361473 CHEMBL1435274::US12377086, Compound 44

SMILES c1cc2c(ccnc2c(c1)O)C(=O)O

InChI Key InChIKey=KPTUKANGPPVLMD-UHFFFAOYSA-N

Data  2 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50361473   

TargetMetallo-beta lactamase [126-247,M154L](Klebsiella pneumoniae)
TBA

US Patent
LigandPNGBDBM50361473(CHEMBL1435274 | US12377086, Compound 44)
Affinity DataKi:  660nMAssay Description:Nitrocefin (Cayman, CAS 41906-86-9) was used as the chromogenic substrate for all biochemical assays. The enzymatic activity of purified VIM-2 and ND...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
TBA

US Patent
LigandPNGBDBM50361473(CHEMBL1435274 | US12377086, Compound 44)
Affinity DataKi:  670nMAssay Description:VIM-2 was diluted to 6 μM with 50 mM HEPES, pH 7.5, containing 150 mM NaCl. The diluted protein solution was used to make several 5 mL aliquots. L-Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
Go to US Patent

TargetLysine-specific demethylase 4A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50361473(CHEMBL1435274 | US12377086, Compound 44)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of KDM4AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetallo-beta lactamase [126-247,M154L](Klebsiella pneumoniae)
TBA

US Patent
LigandPNGBDBM50361473(CHEMBL1435274 | US12377086, Compound 44)
Affinity DataIC50: 1.90E+3nMAssay Description:Nitrocefin (Cayman, CAS 41906-86-9) was used as the chromogenic substrate for all biochemical assays. The enzymatic activity of purified VIM-2 and ND...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
Go to US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
TBA

US Patent
LigandPNGBDBM50361473(CHEMBL1435274 | US12377086, Compound 44)
Affinity DataIC50: 2.20E+3nMAssay Description:VIM-2 was diluted to 6 μM with 50 mM HEPES, pH 7.5, containing 150 mM NaCl. The diluted protein solution was used to make several 5 mL aliquots. L-Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
Go to US Patent

TargetEgl nine homolog 1(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50361473(CHEMBL1435274 | US12377086, Compound 44)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of PHD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50361473(CHEMBL1435274 | US12377086, Compound 44)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of FIHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed